A year ago, a supermoon unleashed a global nightmare, turning anyone exposed to its light into a savage, bloodthirsty werewolf for a single, terrifying night. As the next supermoon rises, former marine and Global Rapid Response Leader Wesley Marshall (Frank Grillo) teams up with scientists Dr. Aranda (Lou Diamond Phillips) and Dr. Amy Chen (Katrina Law) to find a cure before humanity is lost. As chaos and carnage unfold, Marshall must fight off killer beasts while risking everything to protect his family.